Endocrine Abstracts

Coupling of bone formation subsequent to bone resorption is a fundamental mechanism for sustaining bone density in adults. We have demonstrated that TGFβ1 released from the bone matrix during osteoclastic bone resorption induces the migration of bone marrow mesenchymal stem cells (MSCs). We also found that IGF1 released from bone matrix responsible osteoblast differentiation of MSCs recruited by TGFβ1 during bone remodeling. TGFβ1 released from the bone matrix d...

Introduction and objectives: Circular RNAs (circRNAs) represent a class of endogenous noncoding RNAs that have recently been recognized as important regulators of gene expression and pathological networks. However, investigations on adrenocortical carcinoma (ACC) initiation and progression mechanisms only focus on key encoding genes, but neglect shedding an insight into circRNAs.Materials and methods: We investigated the expression profile of circRNAs in...

Numerous epidemiologic studies have associated hyponatremia with both osteoporosis and bone fractures. Disordered bone metabolism with hyponatremia occurs primarily by direct sodium-sensing mechanisms on osteoclasts that are independent from osmolality. Additional effects may be mediated by arginine vasopressin (AVP) receptors on osteoclasts and osteoblasts. Further, even mild hyponatremia can contribute to neurological dysfunction via gait instability and increased falls, bot...

Context: Type 2 diabetes (T2D) is associated with an increased incidence of infections and several cancers. Although low-grade inflammation and certain immune defects have been found in diabetic patients, the role of adaptive immune response remains to be fully elucidated.Objective: We aimed to explore whether patients with T2D show defects in the activation of T cells.Design: Immune cell phenotypes, T cell functional reactivity, s...

Background: Handgrip strength (HGS) and skeletal muscle mass (SMM) are associated with all-cause and cardiovascular disease (CVD)-specific mortality risk in type 2 diabetes (T2DM) patients. However, the pattern of this association was unclear. We aimed to explore the pattern of associations between HGS and SMM with all-cause and CVD mortality risk in a diabetic population.Method: Data were obtained from the UK Biobank (application number 92014), a large ...

Journal of Endocrinology, 2018, 237(2): 139–152 (DOI: https://doi.org/10.1530/JOE-17-0727)...

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Introduction: Obesity is a major risk factor for the development of hyperlipidemia and its related cardiovascular complications. Apart from its well-established role in cancer biology, the MDM2-p53 axis has been recently shown to regulate glucose and lipid metabolism. Our preliminary data indicated that MDM2 is dramatically induced in the liver of obese mice. In this study, we aimed to investigate the potential role of hepatic MDM2 in controlling systemic lipid homeostasis usi...

Purpose: Subclinical hyperthyroidism is associated with cognitive impairment, but the mechanism has remained unclear. As subclinical hyperthyroidism is characterized by significantly decreased thyrotropin (TSH) levels, this study aimed to investigate whether TSH regulates cognitive function.Methods: The correlation between TSH and cognitive impairment was investigated in a cross-sectional population study including 382 participants wi...

Objective: To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.Methods and Results: A total of 8971 participants aged 40 years and older from Baoshan district, Shanghai were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30...